Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice.
Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice.
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硫利达嗪治疗可改变小鼠克氏锥虫感染的演变。
DOI：
10.1080/00034983.1999.11813474
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发表时间：
1999
影响因子：
--
通讯作者：
P. Paglini
中科院分区：
文献类型：
--
作者：
H. Rivarola;A. Fernández;J. Enders;R. Fretes;S. Gea;M. Suligoy;J. Palma;P. Paglini
硫利达嗪是一种三环药物，已知对克氏锥虫有直接作用，破坏寄生虫的线粒体和动质体。在本研究中，该药物以 80 mg/kg.day 的剂量口服，持续 3 天，以治疗接种少量克氏锥虫的小鼠。该药物对宿主没有造成明显的毒性。它清除了血液中的锥鞭毛体，防止了实验疾病慢性期通常观察到的心脏组织学和功能改变，并且与未经治疗的感染对照相比，大大降低了死亡率。感染后 135 天检查时，治疗小鼠的心脏 β 受体密度和心脏组织学与未感染、未治疗的对照小鼠没有区别。该药物已作为抗精神病药物用于治疗人类。它似乎能够防止克氏锥虫的急性感染演变成慢性疾病，至少在小鼠中如此，并且可能是设计治疗恰加斯病的新药物的有用基础。
Thioridazine, a tricyclic drug, is known to have a direct effect on Trypanosoma cruzi, disrupting the parasites' mitochondria and kinetoplasts. In the present study, the drug was used orally, at 80 mg/kg.day for 3 days, to treat mice inoculated with low numbers of T. cruzi. The drug caused no apparent toxicity in the host. It cleared trypomastigotes from the bloodstream, prevented the histological and functional alterations of the heart normally observed in the chronic phase of the experimental disease, and greatly reduced the mortality rate compared with that in untreated, infected controls. When checked 135 days post-infection, the density of cardiac beta receptors and the cardiac histology of the treated mice were indistinguishable from those of uninfected, untreated controls. The drug is already used to treat humans, as a neuroleptic drug. It appears to be able to prevent acute infection with T. cruzi evolving into chronic disease, at least in mice, and may be a useful base from which to design new agents for the treatment of Chagas disease.
硝呋莫司和苯硝唑这两种用于治疗美洲锥虫病（恰加斯病）的药物的毒性作用。
DOI：
--
发表时间：
1988
期刊：
Biomedical and environmental sciences : BES
影响因子：
--
作者：
Castro,JA;DiazdeToranzo,EG
通讯作者：
DiazdeToranzo,EG
克氏锥虫：感染对大鼠心肌细胞受体介导的变时性和 Ca2+ 动员的影响。
影响因子：
2.1
作者：
Bergdolt,BA;Tanowitz,HB;Wittner,M;Morris,SA;Bilezikian,JP;Moreno,AP;Spray,DC
通讯作者：
Spray,DC