Altered CD8+ T cell responses to selected Epstein-Barr virus immunodominant epitopes in patients with multiple sclerosis
Altered CD8+ T cell responses to selected Epstein-Barr virus immunodominant epitopes in patients with multiple sclerosis
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DOI：
10.1046/j.1365-2249.2003.02114.x
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发表时间：
2003-04-01
影响因子：
4.6
通讯作者：
Haahr, S
中科院分区：
文献类型：
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作者：
Höllsberg, P;Hansen, HJ;Haahr, S
在慢性病毒感染中，抗病毒CD8(+)T细胞的频率增加。在疱疹病毒感染期间，扩增的CD8(+)T细胞被认为控制了潜伏感染的重新激活。由于多发性硬化症(MS)是一种推测的中枢神经系统自身免疫性疾病，与晚期EB病毒(EBV)感染有关，我们希望检查MS患者和健康对照组之间CD8(+)T细胞对EBV表位的反应是否有所不同。在这里，我们报告了在MS患者中，CD8(+)T细胞对核抗原3A(HLAA2/CLG)和潜伏膜蛋白2(HLAB7/RPP)的EBV表位反应的频率增加。值得注意的是，改变的CD8(+)T细胞反应发生在一些但不是所有EBV表位，并且没有达到急性感染时的高水平。MS患者和正常对照组对人巨细胞病毒(HCMV)两个免疫优势表位的反应相似。总之，我们的数据表明，在MS患者中，CD8(+)T细胞与EBV的两个表位反应的频率增加。仅对两个测试的EBV表位的改变反应将与交叉反应表位的存在一致。
An increased frequency of antiviral CD8(+) T cells is seen in chronic viral infections. During herpes virus infections the expanded CD8(+) T cells are thought to control the reactivation of the latent infection. Because multiple sclerosis (MS), a presumed autoimmune disease of the central nervous system, has been associated with a late Epstein-Barr virus (EBV) infection, we wished to examine whether the CD8(+) T cell response to EBV epitopes differed between MS patients and healthy controls. Here we report an increased frequency of CD8(+) T cells responding to EBV epitopes from nuclear antigen 3 A (HLA-A2/CLG) and latent membrane protein 2 (HLA-B7/RPP) in MS patients. Noticeably, the altered CD8(+) T cell response occurred to some but not all EBV epitopes and did not reach the high level seen during acute infection. The responses towards two immunodominant epitopes from human cytomegalovirus (HCMV) were similar in MS patients and normal controls. Together, our data demonstrate the presence of an increased frequency of CD8(+) T cells reacting with two epitopes from EBV in patients with MS. The altered response to only two of the tested EBV epitopes would be consistent with the presence of cross-reactive epitopes.