Chemical and enzymatic changes in microsomes of chicken livers following stimulation by oestrogens.
Chemical and enzymatic changes in microsomes of chicken livers following stimulation by oestrogens.
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雌激素刺激后鸡肝微粒体的化学和酶促变化。
DOI：
10.1111/j.1432-0436.1974.tb00351.x
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
B. Wanamacher
中科院分区：
文献类型：
--
作者：
O. Schjeide;R. Prince;T. Nicholls;B. Wanamacher
对小鸡、小母鸡或公鸡施用雌激素物质会导致其肝脏内质网 (E.R.) 的膜和核糖体成分快速广泛增殖，为卵黄蛋白的合成做好准备。在这种情况下，肝微粒体最初表现出许多化学和酶学特征，这些特征先前被描述为在鸡胚胎肝脏中快速扩展 E.R.。此外，还发现微粒体部分（主要是 E.R.）与“微粒体后”脂蛋白部分在酶学上相关，并且可能与其保持平衡，该部分不呈现与传统膜相同的形态。 600R 全身 X 射线照射被发现可以快速抑制肝脏 E.R. 和“微粒体后”成分的增殖，这是通过抑制雌激素引起的正常发生的酶变化来检测的，在粗糙 E.R. 的情况下，通过减少核糖体 RNA 的净合成来检测。
Administration of oestrogenic substances to chicks, pullets or roosters results in rapid and extensive proliferation of membraneous and ribosomal components of the endoplasmic reticula (E.R.) of their livers in preparation for the synthesis of yolk proteins. Under such circumstances, the liver microsomes initially display many of the chemical and enzymatic characteristics previously delineated for rapidly expanding E.R. in the livers of chicken embryos. In addition, it was found that the microsomal fraction (mostly E.R.) is enzymatically related to, and is possibly in equilibrium with, a ‘post-microsomal’ lipoprotein fraction which does not present the same morphology as the conventional membrane. 600R of whole body X-irradiation was found to quickly inhibit proliferation of both liver E.R. and ‘post-microsomal’ elements, as detected by inhibition of normally occurring enzyme changes provoked by oestrogen administration and, in the case of rough E.R., by a reduction in the net synthesis of ribosomal RNA.