Postoperative efficacy of low-temperature plasma radiofrequency ablation in elderly patients with laryngeal carcinoma and its influences on tumor markers and COX-2 and VEGF expressions in laryngeal carcinoma tissues.
Postoperative efficacy of low-temperature plasma radiofrequency ablation in elderly patients with laryngeal carcinoma and its influences on tumor markers and COX-2 and VEGF expressions in laryngeal carcinoma tissues.
复制标题
低温等离子射频消融治疗老年喉癌术后疗效及其对喉癌组织肿瘤标志物及COX-2、VEGF表达的影响
DOI：
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Jianing Xi
中科院分区：
文献类型：
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作者：
Xin Dai;B. Wei;Yuan He;Qian Zhang;Jianing Xi
目的
观察低温等离子射频消融术治疗老年喉癌的疗效及对喉癌组织中肿瘤标志物环氧化酶2（考克斯-2）和血管内皮生长因子（VEGF）表达的影响。
方法
选取2015年1月至2018年1月在我院行低温等离子射频消融术的老年喉癌患者50例为观察组，另选取50例接受常规手术治疗的老年喉癌患者为对照组。疗程结束时，观察两组患者的疗效及术后并发症，记录手术时间、疼痛视觉模拟评分（VAS）及黏膜恢复评分。同时检测两组喉癌组织中肿瘤标志物糖类抗原125（CA 125）、CA 199和癌胚抗原（CEA）的水平，并采用免疫组化和定量聚合酶链反应（PCR）检测考克斯-2和VEGF的表达。
结果
研究组有效率明显高于对照组（P<0.05），研究组术后并发症例数明显减少（P<0.05）。此外，研究组的手术时间明显短于对照组，VAS疼痛评分和粘膜恢复评分明显低于对照组（p<0.05）。喉癌组织中肿瘤标志物CA 125、CEA、CA 19.9水平及考克斯-2、VEGF表达水平均明显降低（p<0.05）。
结论
低温等离子射频消融术治疗老年喉癌患者疗效较好，术后并发症少，术后肿瘤标志物及喉癌组织中考克斯-2、VEGF表达水平降低，总体疗效较好，具有显著的应用价值，值得临床尝试。
PURPOSE
To observe the postoperative efficacy of low-temperature plasma radiofrequency ablation in treating elderly patients with laryngeal carcinoma and its influence on the tumor markers, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expressions in laryngeal carcinoma tissues.
METHODS
A total of 50 elderly laryngeal carcinoma patients undergoing low-temperature plasma radiofrequency ablation in our hospital from January 2015 to January 2018 were enrolled as observation group, and another 50 elderly laryngeal carcinoma patients receiving conventional surgical treatment as control group. At the end of the treatment course, the efficacy and postoperative complications in the patients were observed, the operation time and pain visual analogue scale (VAS) and mucosal recovery scores were recorded. Besides, the levels of the tumor markers carbohydrate antigen 125 (CA125), CA199 and carcinoembryonic antigen (CEA) were determined, and the expressions of COX-2 and VEGF in laryngeal carcinoma tissues in the two groups were detected using immunohistochemistry and quantitative polymerase chain reaction (PCR).
RESULTS
The efficacy in the study group was obviously higher than in the control group (p<0.05), and the cases of postoperative complications declined evidently in the study group (p<0.05). Moreover, the study group exhibited distinctly shorter operation time and lower VAS pain and mucosal recovery scores than the control group (p<0.05). The levels of the tumor markers CA125, CEA and CA19.9 and the expression levels of COX-2 and VEGF in laryngeal carcinoma tissues were substantially lowered in the study group (p<0.05).
CONCLUSIONS
Low-temperature plasma radiofrequency ablation has better efficacy in treating elderly laryngeal carcinoma patients, with few postoperative complications, and decreased expression levels of postoperative tumor markers as well as COX-2 and VEGF in laryngeal carcinoma tissues, and it offers better overall effect and notable application value, therefore it is worth trying it in clinical practice.
影响因子：
2.8
作者：
Ishibashi, Hidenobu;Tonomura, Hitoshi;Kubo, Toshikazu
通讯作者：
Kubo, Toshikazu