THE GENETIC-BASIS OF COMPLEX HUMAN BEHAVIORS
THE GENETIC-BASIS OF COMPLEX HUMAN BEHAVIORS
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DOI：
10.1126/science.8209254
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发表时间：
1994-06-17
期刊：
影响因子：
56.9
通讯作者：
MCGUFFIN, P
中科院分区：
文献类型：
--
作者：
PLOMIN, R;OWEN, MJ;MCGUFFIN, P
定量遗传研究已经为遗传因素在许多复杂的行为障碍和精神病理学、人格和认知能力领域的重要性建立了强有力的案例。定量遗传学还可以为分子遗传学的应用提供经验指导和概念框架。分子遗传学在阐明行为障碍的遗传基础方面的成功在很大程度上依赖于一种简化的一基因一障碍（OGOD）方法，在这种方法中，单个基因是必要的，足以形成一种疾病。相比之下，数量性状位点（QTL）方法涉及寻找多个基因，每个基因对于一个性状的发展既不是必要的，也不是充分的。在鉴定影响人类复杂行为的基因方面，OGOD和QTL方法各有优缺点。
Quantitative genetic research has built a strong case for the importance of genetic factors in many complex behavioral disorders and dimensions in the domains of psychopathology, personality, and cognitive abilities. Quantitative genetics can also provide an empirical guide and a conceptual framework for the application of molecular genetics. The success of molecular genetics in elucidating the genetic basis of behavioral disorders has largely relied on a reductionistic one gene, one disorder (OGOD) approach in which a single gene is necessary and sufficient to develop a disorder. In contrast, a quantitative trait loci (QTL) approach involves the search for multiple genes, each of which is neither necessary nor sufficient for the development of a trait. The OGOD and QTL approaches have both advantages and disadvantages for identifying genes that affect complex human behaviors.