OSCILLATIONS OF CYTOSOLIC CALCIUM IN RAT CHROMAFFIN CELLS - DUAL MODULATION IN FREQUENCY AND AMPLITUDE
OSCILLATIONS OF CYTOSOLIC CALCIUM IN RAT CHROMAFFIN CELLS - DUAL MODULATION IN FREQUENCY AND AMPLITUDE
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DOI：
10.1006/bbrc.1994.2801
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发表时间：
1994-12-15
影响因子：
3.1
通讯作者：
GROHOVAZ, F
中科院分区：
文献类型：
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作者：
DANDREA, P;CODAZZI, F;GROHOVAZ, F
原代培养的大鼠染色质细胞有很高的倾向表现出[Ca2+](i)振荡，自发或经过适度刺激，诱导多磷酸肌醇水解或轻度去极化处理。先前对各种细胞系统的研究表明，上述处理的加强增加了振荡的频率而不是幅度。我们现在证明，在培养的染色质细胞中，这些振荡增强中的任何一个都可以被激发，这取决于应用刺激诱导的Ca2+内流是否与振荡的[Ca2+](i)尖峰同步或定时。因此，在可兴奋细胞中，振荡活动的编码似乎不仅根据数字（频率调制）而且根据模拟（幅度调制）模型进行操作。(C) 1994学术出版社，Inc.
Rat chromaffin cells in primary culture have a high tendency to exhibit [Ca2+](i) oscillations, spontaneously or after moderate stimulation with treatments that induce polyphosphoinositide hydrolysis or mild depolarization. Previous studies in a variety of cell systems had shown that strengthening of the above treatments increases the frequency and not the amplitude of the oscillations. We now demontrate that in cultured chromaffin cells either one of these oscillation reinforcements can be elicited, depending on whether the Ca2+ influx induced by the applied stimulus is asynchronous with or timed by the [Ca2+](i) spikes of the oscillations. In excitable cells the encoding of the oscillation activity appears therefore to operate according to not only digital (modulation in frequency) but also analog (modulation in amplitude) models. (C) 1994 Academic Press, Inc.