Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis
Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis
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DOI：
10.1016/j.neures.2007.06.1465
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Ishida, Yasushi
中科院分区：
文献类型：
--
作者：
Abe, Hiroshi;Hidaka, Noriko;Ishida, Yasushi
在人类中，怀孕期间的压力事件可能会增加后代患精神疾病的风险，对啮齿动物的研究发现，产前的身体压力会导致后代的生理学，神经生物学和行为发生变化。在本研究中，我们研究了心理产前压力与小的物理压力是否会导致神经生物学和行为的后代在Sprague-Dawley大鼠的变化，作为物理产前压力。在妊娠的最后三个月，通过观察在社交交流箱中的透明墙壁后面电击的大鼠，母鼠接受心理压力，但未暴露于任何身体压力。与未治疗母鼠的大鼠相比，暴露于心理压力的母鼠的雄性后代在开阔场地测试中表现出情绪增强，在强迫游泳测试中表现出抑郁样行为，并且下丘脑-垂体-肾上腺轴的活动增强。然而，产前应激大鼠表现出完整的能力，获得条件反射。这是第一份报告，产前心理压力的沟通箱可以导致神经生物学和行为的变化，在啮齿动物的后代。(C)2007 Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
In humans, stressful events during pregnancy may raise the risk of psychiatric disorders in offspring, and studies with rodents have found that physical prenatal stress can cause changes in the physiology, neurobiology, and behavior of offspring. In the present study, we examined whether psychological prenatal stress with little physical stress could cause changes in the neurobiology and behavior of offspring in Sprague-Dawley rats, as physical prenatal stress did. Dams received psychological stress by observing a rat being electrically shocked behind a transparent wall in the social communication box during the last trimester of gestation but were not exposed to any physical stress. Male offspring from the dams exposed to psychological stress showed enhanced emotionality in an open field test, depression-like behavior in a forced swim test, and enhanced activity in the hypothalamo-pituitary-adrenal axis, compared with rats from untreated dams. However, the prenatally stressed rats showed intact ability to acquire context conditioning. This is the first report that psychological prenatal stress in the communication box can cause changes in the neurobiology and behavior of offspring in rodents. (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.