Genetics of diabetic nephropathy
Genetics of diabetic nephropathy
复制标题
DOI：
10.1590/s0004-27302010000300002
复制
发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Crispim, Daisy
中科院分区：
文献类型：
--
作者：
Carpena, Mariana P.;Rados, Dimitris V.;Crispim, Daisy
糖尿病患病率的增加导致了越来越多的慢性并发症，包括糖尿病肾病（DN）。除了发病率高之外，DN 还与高发病率和死亡率相关，尤其是心血管疾病。众所周知，遗传因素在 DN 的发病机制中发挥着作用，遗传易感个体在暴露于环境因素后可能会患上 DN。 DN 可能是一种复杂的多基因疾病。已使用两种主要策略来识别与 DN 相关的基因：候选基因分析，以及最近的全基因组扫描。人们已经付出了巨大的努力来识别这些主要基因，但结果仍然与与特定人群中的微小影响相关的不同基因不一致。主要基因的鉴定将有助于检测 DN 高风险个体，并更好地了解其病理生理学。 Arq Bras 内分泌代谢，2010；54(3):253-61
The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well. Arq Bras Endocrinol Metab, 2010;54(3):253-61