MURINE WNT-11 AND WNT-12 HAVE TEMPORALLY AND SPATIALLY RESTRICTED EXPRESSION PATTERNS DURING EMBRYONIC-DEVELOPMENT
MURINE WNT-11 AND WNT-12 HAVE TEMPORALLY AND SPATIALLY RESTRICTED EXPRESSION PATTERNS DURING EMBRYONIC-DEVELOPMENT
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DOI：
10.1016/0925-4773(95)00383-5
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发表时间：
1995-06-01
影响因子：
2.6
通讯作者：
WAINWRIGHT, BJ
中科院分区：
文献类型：
--
作者：
CHRISTIANSEN, JH;DENNIS, CL;WAINWRIGHT, BJ
Wnt 基因家族编码一组与多种生物体发育有关的信号分子。我们最近克隆了鼠 Wnt-11 和 Wnt-12 的部分 cDNA 序列。在这里，我们描述了小鼠胚胎发生过程中这两个基因的时空表达模式。 Wnt-11 表达首先在 8.25 dpc 的动脉干内检测到。到 9.5 dpc 时，在皮节和肌节内侧交界处的体节中检测到 Wnt-11 表达。从芽首次可见时起，Wnt-11 转录物也在肢芽间充质中检测到。从 10.5 dpc 起，在顶端外胚层嵴中检测到 Wnt-12。讨论了这些表达模式的含义。
The Wnt gene family encodes a set of signalling molecules implicated in the development of a wide range of organisms. We have recently cloned partial cDNA sequences of murine Wnt-11 and Wnt-12. Here, we describe the spatio-temporal expression patterns of both genes during mouse embryogenesis. Wnt-11 expression is first detected within the truncus arteriosus from 8.25 dpc. By 9.5 dpc, Wnt-11 expression is detected in the somites at the medial junction of the dermatome and the myotome. Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed.