Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias.
Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias.
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DOI：
10.3390/ijms17010052
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发表时间：
2015-12-31
影响因子：
5.6
通讯作者：
Dudley SC Jr
中科院分区：
文献类型：
--
作者：
Liu M;Dudley SC Jr
未折叠蛋白反应(UPR)在神经系统疾病和糖尿病中得到了广泛的研究，但对其在心脏病中的作用却知之甚少。活化的UPR参与多种心脏疾病，既可以保护心脏功能，也可以损害心脏功能。最近发现，UPR通过影响心脏离子通道的表达而在人类心力衰竭的心律失常发生中发挥作用，阻断UPR具有抗心律失常的作用。这篇综述将讨论心脏疾病治疗心律失常的靶向UPR的原理和挑战。
The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.