PYRIPYROPENES, NOVEL ACAT INHIBITORS PRODUCED BY ASPERGILLUS-FUMIGATUS .3. STRUCTURE ELUCIDATION OF PYRIPYROPENES E TO L
PYRIPYROPENES, NOVEL ACAT INHIBITORS PRODUCED BY ASPERGILLUS-FUMIGATUS .3. STRUCTURE ELUCIDATION OF PYRIPYROPENES E TO L
复制标题
DOI：
10.7164/antibiotics.48.495
复制
发表时间：
1995-06-01
影响因子：
3.3
通讯作者：
KANEKO, T
中科院分区：
文献类型：
--
作者：
TOMODA, H;TABATA, N;KANEKO, T
从烟曲霉（Aspergillus fumigatus） FO-1289-2501高产菌株培养液中分离到8个新的pyripypypenes，从E到L。结构分析表明，所有的pyripyropenes与pyripyropenes A ~ d具有相同的pyridino- α - pyroone倍半萜核心，其中pyripyropenes L对大鼠肝微粒体中酰基辅酶A：胆固醇酰基转移酶（ACAT）活性的抑制作用最强，IC50值为0.27 μ M。
Eight new pyripyropenes, E to L, were isolated from the culture broth of Aspergillus fumigatus FO-1289-2501 selected as a higher producer by NTG mutation. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to D. Among them, pyripyropene L showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 value of 0.27 mu M in rat liver microsomes.