Yonemitsu-type Condensations Catalysed by Proline and Eu(OTf)3
Yonemitsu-type Condensations Catalysed by Proline and Eu(OTf)3
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脯氨酸和 Eu(OTf)3 催化的米光型缩合反应
DOI：
10.1039/c4ra08853k
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
A. Fontana
中科院分区：
文献类型：
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作者：
A. Renzetti;E. Boffa;M. Colazzo;S. Gerard;J. Sapi;T.-H. Chan;H. Nakazawa;C. Villani;A. Fontana
我们报道了芳族杂环、醛和活性亚甲基化合物的米光型三分子缩合，以提供多官能化杂环。该反应由 L-脯氨酸和 Eu(OTf)3 催化，在室温下于甲醇中进行，并且在某些情况下具有高度非对映选择性（d.e> 90%）。相对于之前报道的 Ti(IV) 促进的缩合反应，该反应具有两个优点：（1）它遵循绿色化学的一些原则，（2）它提供了获得经典方法无法获得的化合物的途径。
We report a Yonemitsu-type trimolecular condensation of aromatic heterocycles, aldehydes, and active methylene compounds to afford polyfunctionalised heterocycles. The reaction is catalysed by L-proline and Eu(OTf)3, takes place in methanol at room temperature, and in some cases is highly diastereoselective (d.e. >90%). The reaction offers two advantages with respect to the previously reported Ti(IV)-promoted condensation: (1) it adheres to some principles of green chemistry, and (2) it provides access to compounds that cannot be obtained by classical methodology.