Genome scan of Han Chinese schizophrenia families from Taiwan: Confirmation of linkage to 10q22.3
Genome scan of Han Chinese schizophrenia families from Taiwan: Confirmation of linkage to 10q22.3
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DOI：
10.1176/appi.ajp.163.10.1760
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发表时间：
2006-10-01
影响因子：
17.7
通讯作者：
Tsuang, Ming T.
中科院分区：
文献类型：
--
作者：
Faraone, Stephen V.;Hwu, Hai-Gwo;Tsuang, Ming T.
目的：精神分裂症的全基因组连锁分析已经确定了几个可能含有精神分裂症易感基因的区域，但考虑到该疾病的复杂病因，不太可能检测到所有易感区域。为了解决这个问题，作者确定了606个汉族家庭，包括1,234名受影响的members.Method：先证者与精神分裂症，从六个数据收集现场研究中心在台湾招募。每个先证者都接受了诊断筛查，并补充了医疗记录和半结构化访谈。在此筛选后，作者进行了普通话中文版的遗传研究诊断访谈。最佳估计的最终诊断是由两名委员会认证的精神病学家作出的。基因分型由遗传疾病研究中心进行，386个标记的平均间隔为9厘摩（cM）。实证模拟产生，以确定全基因组significance.Results：作者发现5个区域的非参数连锁z分数2.0或更大。这些建议如下：D1 S551达到2.08 D2 S410在1p31.1和2.31处为（113.7）cM（125.2 cM）; D4 S2361达到2.00 D15 S1012在4q21.23（93.5 cM）和15 q14（36 cM）的最大非参数连锁z得分为2.07，D10 S2327的最大非参数连锁z得分为2.88结论：10q22.3在100.9cM处的发现与先前报道的10号染色体上107.2cM处的非参数连锁评分4.27相一致，尽管在本研究中没有达到全基因组意义。
Objective: Genome-wide linkage analyses of schizophrenia have identified several regions that may harbor schizophrenia susceptibility genes, but given the complex etiology of the disorder, it is unlikely that all susceptibility regions have been detected. To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members.Method: Probands with schizophrenia were recruited from six data collection field research centers in Taiwan. Each proband underwent a diagnostic screen with supplemental medical records and a semistructured interview. Following this screen, the authors administered the Mandarin Chinese version of the Diagnostic Interview for Genetic Studies. Best-estimate final diagnoses were made by two board-certified psychiatrists. The genotyping was conducted by the Center for Inherited Disease Research, with 386 markers spaced at an average of 9-centimorgan (cM) intervals. Empirical simulations were generated to determine genome-wide significance.Results: The authors found five regions with nonparametric linkage z scores 2.0 or greater. These were the following: 2.08 was reached for D1S551 (113.7) cM at 1p31.1 and 2.31 for D2S410 (125.2 cM) at 2q14.1; 2.00 was reached for D4S2361 (93.5 cM) at 4q21.23, and 2.07 for D15S1012 (36 cM) at 15q14, the largest nonparametric linkage z score was 2.88 for D10S2327 (100.92 cM) at 10q22.3.Conclusions: Our 10q22.3 finding at 100.9 cM is consistent with a previously reported nonparametric linkage score of 4.27 at 107.2 cM on chromosome 10, although it did not attain genome-wide significance in this study.