Functional imaging of working memory after 24 hr of total sleep deprivation
Functional imaging of working memory after 24 hr of total sleep deprivation
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DOI：
10.1523/jneurosci.0007-04.2004
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发表时间：
2004-05-12
影响因子：
5.3
通讯作者：
Choo, WC
中科院分区：
文献类型：
--
作者：
Chee, MWL;Choo, WC
应用功能磁共振成像技术研究了24小时完全睡眠剥夺（SD）对健康青年工作记忆的神经行为影响。两个任务，一个测试维护和其他操作和维护，被使用。SD后，两项任务的响应时间明显变慢。在更复杂的任务中，表现更好。这两项任务都激活了一个左右半球占主导地位的额顶叶脑区网络，反映了语言工作记忆的参与。在这两种状态下，操作引起更广泛和双边（L>R）额叶，顶叶和丘脑激活。SD后，有减少的血氧水平依赖的信号反应，在顶叶内侧区与两个任务。减少失活的前内侧额叶和后扣带区域观察到这两个任务。最后，当需要操作时，左侧背外侧前额叶皮层和双侧丘脑的激活程度不成比例地更高。这种激活和失活的变化模式与健康老年人执行类似任务时观察到的相似。我们的数据表明，减少激活和减少失活可能是SD后认知功能障碍的基础，增加前额叶和丘脑激活可能代表代偿性适应。额外的左额叶激活后SD被假定为任务依赖性和偶然的任务复杂性。我们的研究结果提供了神经相关性，以解释为什么相对较复杂的任务中的任务表现相对于SD后的简单任务更好地保留。
The neurobehavioral effects of 24 hr of total sleep deprivation (SD) on working memory in young healthy adults was studied using functional magnetic resonance imaging. Two tasks, one testing maintenance and the other manipulation and maintenance, were used. After SD, response times for both tasks were significantly slower. Performance was better preserved in the more complex task. Both tasks activated a bilateral, left hemisphere-dominant frontal-parietal network of brain regions reflecting the engagement of verbal working memory. In both states, manipulation elicited more extensive and bilateral (L>R) frontal, parietal, and thalamic activation. After SD, there was reduced blood oxygenation level-dependent signal response in the medial parietal region with both tasks. Reduced deactivation of the anterior medial frontal and posterior cingulate regions was observed with both tasks. Finally, there was disproportionately greater activation of the left dorsolateral prefrontal cortex and bilateral thalamus when manipulation was required. This pattern of changes in activation and deactivation bears similarity to that observed when healthy elderly adults perform similar tasks. Our data suggest that reduced activation and reduced deactivation could underlie cognitive impairment after SD and that increased prefrontal and thalamic activation may represent compensatory adaptations. The additional left frontal activation elicited after SD is postulated to be task dependent and contingent on task complexity. Our findings provide neural correlates to explain why task performance in relatively more complex tasks is better preserved relative to simpler ones after SD.