Relationship between α7 nAChR and apoptosis in human lymphocytes
Relationship between α7 nAChR and apoptosis in human lymphocytes
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DOI：
10.1016/j.jneuroim.2004.11.010
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Bouzat, C
中科院分区：
文献类型：
--
作者：
De Rosa, MJ;Esandi, MD;Bouzat, C
已经证明血细胞中存在烟碱受体（nAChR）。然而，人们对其功能作用知之甚少。我们检测了人外周血淋巴细胞中α 7 nAChR的mRNA，并确定其表达在个体之间和同一个体在不同时间内具有高度可变性。淋巴细胞与尼古丁或α-银环蛇毒素孵育后，系统观察到α 7的上调。此外，与这些药物一起孵育降低了暴露于皮质醇诱导的凋亡细胞的百分比。我们的研究结果表明，α 7 nAChRs参与皮质醇诱导的细胞凋亡的调制。(c)2004 Elsevier B. V.保留所有权利。
The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of alpha 7 nAChR in peripheral human lymphocytes and determined that its expression is highly variable among individuals and within the same individual at different times. Upregulation of alpha 7 is systematically observed after incubation of lymphocytes with nicotine or alpha-bungarotoxin. In addition, the incubation with these drugs decreases the percentage of apoptotic cells induced by the exposure to cortisol. Our results suggest that alpha 7 nAChRs are involved in the modulation of cortisol-induced apoptosis. (c) 2004 Elsevier B.V. All rights reserved.