Ultrasonically sculpted virtual relay lens for in situ microimaging
Ultrasonically sculpted virtual relay lens for in situ microimaging
复制标题
DOI：
10.1038/s41377-019-0173-7
复制
发表时间：
2019-07-17
影响因子：
19.4
通讯作者：
Chamanzar, Maysamreza
中科院分区：
文献类型：
--
作者：
Scopelliti, Matteo Giuseppe;Chamanzar, Maysamreza
我们通过介质演示了原位非侵入性中继成像，无需插入物理光学组件。我们证明，可以使用原位可重构超声波干涉图案在介质中雕刻虚拟光学渐变折射率（GRIN）透镜，以通过介质传递图像。超声波图案改变介质的局部密度，以塑造垂直于光传播方向的渐变折射率图案，从而调制光的相前，使其在介质内聚焦并有效地创建虚拟中继透镜。我们演示了通过通常不透明的浑浊介质（光学厚度 = 5.7 倍散射平均自由程）进行的原位中继成像和小特征（22 μ m）的解析。雕刻光学GRIN透镜的焦距和数值孔径可以通过改变超声波参数来调节。例如，我们通过实验证明，轴向焦距可以在调制介质中 5.4 mm 的深度上连续扫描，并且数值孔径可以调谐至 21.5%。超声波和光的相互作用可以通过不同的物理介质来介导，包括生物组织等浑浊介质，其中超声雕刻的GRIN透镜可用于通过浑浊介质传递底层结构的图像，从而为植入侵入性内窥镜提供了潜在的替代方案。
We demonstrate in situ non-invasive relay imaging through a medium without inserting physical optical components. We show that a virtual optical graded-index (GRIN) lens can be sculpted in the medium using in situ reconfigurable ultrasonic interference patterns to relay images through the medium. Ultrasonic wave patterns change the local density of the medium to sculpt a graded refractive index pattern normal to the direction of light propagation, which modulates the phase front of light, causing it to focus within the medium and effectively creating a virtual relay lens. We demonstrate the in situ relay imaging and resolving of small features (22 mu m) through a turbid medium (optical thickness = 5.7 times the scattering mean free path), which is normally opaque. The focal distance and the numerical aperture of the sculpted optical GRIN lens can be tuned by changing the ultrasonic wave parameters. As an example, we experimentally demonstrate that the axial focal distance can be continuously scanned over a depth of 5.4 mm in the modulated medium and that the numerical aperture can be tuned up to 21.5%. The interaction of ultrasonic waves and light can be mediated through different physical media, including turbid media, such as biological tissue, in which the ultrasonically sculpted GRIN lens can be used for relaying images of the underlying structures through the turbid medium, thus providing a potential alternative to implanting invasive endoscopes.