Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study.
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study.
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DOI：
10.3389/fcvm.2021.745758
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发表时间：
2021
影响因子：
3.6
通讯作者：
Abid L
中科院分区：
文献类型：
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作者：
Charfeddine S;Ibn Hadj Amor H;Jdidi J;Torjmen S;Kraiem S;Hammami R;Bahloul A;Kallel N;Moussa N;Touil I;Ghrab A;Elghoul J;Meddeb Z;Thabet Y;Kammoun S;Bouslama K;Milouchi S;Abdessalem S;Abid L
COVID-19疾病是一种多系统疾病，部分原因是血管内皮损伤。感染后可能会持续存在持久效应和长期后遗症，可能是由于持续的内皮功能障碍。我们的研究重点是在一个大型COVID-19长期患者队列中通过手指热监测与E4诊断Polymath评估内皮质量指数（EQI），以确定长期COVID-19症状是否与内皮功能障碍相关。这是一项前瞻性招募患者的横断面多中心观察性研究。本研究共纳入798例患者。共有618名患者（77.4%）有长期COVID-19症状。平均EQI为2.02 ± 0.99 IC95% [1.95-2.08]。共有397例（49.7%）患者EQI受损。在调整年龄、性别、糖尿病、高血压、血脂异常、冠心病和急性COVID-19感染的严重程度后，疲劳、胸痛和神经认知困难与EQI <2的内皮功能障碍显著相关。在多变量分析中，内皮功能障碍（EQI <2）、女性和急性COVID-19感染时的严重临床状态需要补充氧气是COVID-19长期综合征的独立危险因素。长期的COVID-19症状，特别是非呼吸道症状，是由于持续的内皮功能障碍。这些发现可以更好地照顾有长期COVID-19症状的患者。
The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC95% [1.95–2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.