Mycosis fungoides in relation to environmental exposures and immune response: a case-control study.
Mycosis fungoides in relation to environmental exposures and immune response: a case-control study.
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蕈样肉芽肿与环境暴露和免疫反应的关系：病例对照研究。
DOI：
10.1093/jnci/81.20.1560
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gibney,C
中科院分区：
文献类型：
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作者：
Whittemore,AS;Holly,EA;Lee,IM;Abel,EA;Adams,RM;Nickoloff,BJ;Bley,L;Peters,JM;Gibney,C
蕈样肉芽肿是一种病因不明的皮肤T细胞淋巴瘤，被认为是一种罕见的慢性抗原刺激后遗症，可能发生，例如，与接触过敏原。为了探索这种可能性，我们在旧金山、弗朗西斯科、洛杉矶和西雅图地区采访了174名蕈样肉芽肿患者和294名随机选择的对照受试者，询问他们的职业史、化学品暴露史、过敏史、特应性反应史和某些医疗状况。患者报告非霍奇金淋巴瘤和皮肤癌以外的癌症患病率更高（相对风险= 3.3，P < .001），并且在暴露于阳光下时比对照组更有可能被烧伤（对于非黑人，相对风险= 1.7，P = 0.01）。01）。后一种差异可能反映了疾病的一种表现，而不是前兆。我们没有发现病人和对照组之间在工作类型、职业性或非职业性化学品暴露方面存在一致或生物学上合理的差异。这些发现并不支持这样的假设，即持续的抗原刺激接触过敏原是重要的蕈样肉芽肿的发病机制的病因。[国家癌症研究所杂志81：1560-1567，1989]
Mycosis fungoides is a cutaneous T-cell lymphoma of unknown etiology, thought to be a rare sequela of chronic antigenic stimulation that may occur, for example, with exposure to contact allergens. To explore this possibility, we interviewed 174 patients with mycosis fungoides and 294 randomly selected control subjects in the San Francisco, Los Angeles, and Seattle areas concerning their lifetime histories of employment, chemical exposures, allergy, atopy, and certain medical conditions. Patients reported higher prevalence of cancers other than the non-Hodgkin's lymphomas and skin cancers (relative risk = 3.3,P< .001) and were more likely than controls to burn when exposed to the sun (for nonblacks, relative risk = 1.7,P= .01). The latter difference may reflect a manifestation rather than a precursor of the disease. We found no consistent or biologically plausible differences between patients and controls with respect to types of jobs held, or to occupational or avocational exposures to chemicals. These findings do not support the hypothesis that persistent antigenic stimulation by contact allergens is etiologically important in the pathogenesis of mycosis fungoides. [J Natl Cancer Inst 81:1560–1567, 1989]