Usefulness of EQUAL Candida Score for predicting outcomes in patients with candidaemia: a retrospective cohort study
Usefulness of EQUAL Candida Score for predicting outcomes in patients with candidaemia: a retrospective cohort study
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DOI：
10.1016/j.cmi.2020.01.029
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发表时间：
2020-11-01
影响因子：
14.2
通讯作者：
Lin, Shang-Yi
中科院分区：
文献类型：
--
作者：
Huang, Ho-Yin;Lu, Po-Liang;Lin, Shang-Yi
Background: The European Confederation of Medical Mycology (ECMM) Quality of Clinical Candidaemia Management (EQUAL) score is a tool designed by the ECMM to measure guideline adherence. The current study investigated the association between EQUAL scores and clinical outcomes.Methods: This retrospective study was conducted in three hospitals in Taiwan. Patients with candidae-mia between January 2014 and July 2018 were enrolled. Guideline adherence was evaluated using EQUAL score indicators. Clinical outcomes and predictors of 30-day mortality were investigated.Results: A total of 384 patients were enrolled. The overall mean EQUAL score was 8.91 3.42 (9.42 +/- 3.60 in survivors vs. 8.10 +/- 2.94 in non-survivors, p < 0.001). Higher scores were positively correlated with survival (p < 0.001). Scores of 16-22 indicated the highest survival rates (p for trend 0.001). The Kaplan Meier plot revealed that patients with EQUAL scores 10. Multivariable analysis revealed that EQUAL scores 10 (odds ratio (OR) 0.37, 95% confidence interval (CI) 0.19-0.74), advanced age (OR 1.02, 95% CI 1.00-1.04), septic shock (OR 4.42, 95% CI 2.09-9.36), high sequential organ failure assessment scores (OR 4.28, 95% CI 2.15 8.52), intravascular catheter-related source (OR 0.42, 95% CI 0.19-0.94) and central venous catheter retention (OR 5.41, 95% CI 2.06-14.24) were independent predictors of 30-day mortality.Discussion: Greater guideline adherence with a higher EQUAL score was significantly associated with survival. An EQUAL score cutoff point
