HGF/Met Signaling in Cancer Invasion: The Impact on Cytoskeleton Remodeling.
HGF/Met Signaling in Cancer Invasion: The Impact on Cytoskeleton Remodeling.
复制标题
HGFMet 信号在癌症侵袭中对细胞骨架重塑的影响
DOI：
10.3390/cancers9050044
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发表时间：
2017-05-05
期刊：
影响因子：
5.2
通讯作者：
Fu P
中科院分区：
文献类型：
--
作者：
Xiang C;Chen J;Fu P
The invasion of cancer cells into surrounding tissue and the vasculature is essential for tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) induces cancer cell migration and invasion. A broad spectrum of mechanisms underlies cancer cell migration and invasion. Cytoskeletal reorganization is of central importance in the development of the phenotype of cancer cells with invasive behavior. Through their roles in cell mechanics, intracellular trafficking, and signaling, cytoskeleton proteins participate in all essential events leading to cell migration. HGF has been involved in cytoskeleton assembly and reorganization, and its role in regulating cytoskeleton dynamics is still expanding. This review summarizes our current understanding of the role of HGF in regulating cytoskeleton remodeling, distribution, and interactions.
