Novel cyclourethane-derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
Novel cyclourethane-derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
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DOI：
10.1016/s0960-894x(02)00300-1
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发表时间：
2002-08-05
影响因子：
2.7
通讯作者：
Buthod, J
中科院分区：
文献类型：
--
作者：
Ghosh, AK;Swanson, LM;Buthod, J
设计合成了一系列新型的含(R)-羟乙胺基异构体的大环氨酯。考察了环的大小和取代基的影响。含14-16元环的环烷类化合物对HIV-1蛋白水解酶表现出较低的纳米分子抑制活性。(C)2002爱思唯尔科学有限公司。保留所有权利。
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease. (C) 2002 Elsevier Science Ltd. All rights reserved.