Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia.
Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia.
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DOI：
10.1371/journal.pone.0133622
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu T;Lu QB;Yan L;Guo J;Feng F;Qiu J;Wang J
精神分裂症的病因学和病理生理学仍不清楚。本研究探讨了精神分裂症的危险性与血清中10种微量元素水平的关系。进行1：1配对病例对照研究，按年龄和性别配对。采集血样，通过电感耦合等离子体质谱法测定镍、钼、砷、铝、铬、锰、硒、铜、铁和锌的浓度。采用条件Logistic回归模型分析微量元素与精神分裂症发病风险的关系。研究对象为114例精神分裂症患者和114名健康对照者。多因素分析显示，铜≤0.97 μg/mL、硒≤72 ng/mL、锰>3.95 ng/mL与精神分裂症的危险性增加有关。研究表明，与健康对照组相比，精神分裂症患者体内硒、铜的含量较低，锰的含量较高。
The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected to determine the concentrations of nickel, molybdenum, arsenic, aluminum, chromium, manganese, selenium, copper, iron and zinc by an inductively coupled plasma-mass spectrometry. The conditional logistic regression model was used to analyze the associations between trace elements and schizophrenia risk. Totally 114 schizophrenia patients and 114 healthy controls were recruited in the study. The multivariate analysis demonstrated that copper≤0.97 μg/mL, selenium≤72 ng/mL and manganese>3.95 ng/mL were associated with an increased risk of schizophrenia. The study showed that lower levels of selenium, copper and higher levels of manganese were found in schizophrenia patients compared with healthy controls.