Evaluation of Functional Nerve Recovery after Reconstruction with a New Biodegradable Poly (DL-Lactide-∊-Caprolactone) Nerve Guide
Evaluation of Functional Nerve Recovery after Reconstruction with a New Biodegradable Poly (DL-Lactide-∊-Caprolactone) Nerve Guide
复制标题
使用新型可生物降解聚（DL-丙交酯-∊-己内酯）神经导管重建后功能性神经恢复的评估
DOI：
10.1177/039139889702000809
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Schakenraad
中科院分区：
文献类型：
--
作者：
M. Meek;W. den Dunnen;P. Robinson;A. J. Pennings;J. Schakenraad
本研究的目的是用一种新型的可生物降解的P(DLLA-∊-CL)神经导向器重建大鼠坐骨神经1 cm的缺损区，以评价功能神经的恢复。植入后3~15周进行行走轨迹分析和电刺激试验，以评价运动神经和感觉神经的恢复情况。3周后观察到功能神经恢复的初步迹象。15周后，70%的运动神经和90%的感觉神经功能恢复。与其他研究的结果相比，神经功能的恢复更好。本研究证实了使用可生物降解的p(D11a-∊-CL)神经导向器重建1 cm神经缺损区后，成功地恢复了功能神经。
The aim of this study was to evaluate functional nerve recovery following reconstruction of a 1 cm gap in the sciatic nerve of a rat, using a new biodegradable p (DLLA-∊-CL) nerve guide. To evaluate both motor and sensory nerve recovery, walking track analysis and electrostimulation tests were carried out after implantation periods, ranging from 3 to 15 weeks post-operatively. The first signs of functional nerve recovery were observed after 3 weeks. After 15 weeks, 70% of the motor - and 90% of the sensory nerve function was re-established. Return of nerve function was better, in comparison with results from other studies. This study demonstrated successful functional nerve recovery after the reconstruction of a 1 cm nerve gap with a biodegradable p(DLLA-∊-CL) nerve guide.