NRG Oncology/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update.
NRG Oncology/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update.
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NRG肿瘤学/RTOG共识指南划定临床靶标体积的强度调节骨盆辐射疗法的术后治疗子宫内膜和宫颈癌：更新。
DOI：
10.1016/j.ijrobp.2020.08.061
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Gaffney DK
中科院分区：
文献类型：
--
作者：
Small W Jr;Bosch WR;Harkenrider MM;Strauss JB;Abu-Rustum N;Albuquerque KV;Beriwal S;Creutzberg CL;Eifel PJ;Erickson BA;Fyles AW;Hentz CL;Jhingran A;Klopp AH;Kunos CA;Mell LK;Portelance L;Powell ME;Viswanathan AN;Yacoub JH;Yashar CM;Winter KA;Gaffney DK
2008年，放射治疗肿瘤学组（RTOG）发布了一份国际合作图集，以确定子宫内膜癌和宫颈癌术后盆腔放射治疗的临床靶体积（CTV）。本文利用最近十年关于靶区定义的知识更新了地图集，扩展了地图集，包括主动脉旁区和下闭孔区，并删除了所有关于骨标记的参考。准确的靶区定义是正确应用放射治疗的关键。2008年，放射治疗肿瘤学组（RTOG）发布了一份国际合作图集，以确定强度调节盆腔放射治疗在子宫内膜癌和宫颈癌术后治疗中的临床靶体积（CTV）。目前的项目是更新CTV定义的共识，删除所有涉及骨标记的内容，并包括主动脉旁和闭孔下结区域。一个国际共识指南工作组讨论了当前地图集的修改和争议领域。编写了一份文件以协助拟定定义。一个样本病例腹部骨盆计算机断层图像是可用的，在其上专家轮廓目标。使用期望最大化算法对目标进行一致性分析，以同时进行真理和性能水平估计，并使用kappa统计作为观察者之间一致性的度量。16名参与者提供了13组轮廓。参与者被要求提供以下区域的单独轮廓：阴道袖带、闭孔、髂内、髂外、骶前、髂总和主动脉旁区域。在髂总区有相当一致的结果（敏感性0.71，特异性0.981,kappa 0.64），在髂外、主动脉旁、髂内和阴道袖带区有中等一致的结果（敏感性0.66,0.74,0.62,0.59；特异性0.989,0.966,0.986,0.976；kappa分别为0.60,0.58,0.52,0.47），在骶前和闭孔区有相当一致的结果（敏感性0.55,0.35；特异性0.986,0.988;kappa 0.36, 0.21）。对95%一致的轮廓进行平滑处理，并根据一致性生成最终的轮廓图谱。参与者之间的一致性在髂总区最一致，在骶前和闭孔结区最不一致。一致的体积构成了更新的NRG/RTOG肿瘤术后图谱的基础。鼓励继续研究复发模式，以完善这些卷。
In 2008, the Radiation Therapy Oncology Group (RTOG) published an international collaborative atlas to define the clinical target volume (CTV) for pelvic radiation therapy in the postoperative treatment of endometrial and cervical cancer. This article updates the atlas using the last decade of knowledge on target definitions, expands the atlas to include the para-aortic region and inferior obturator region and removes all references to bony landmarks. Accurate target definition is critical for the appropriate application of radiation therapy. In 2008, the Radiation Therapy Oncology Group (RTOG) published an international collaborative atlas to define the clinical target volume (CTV) for intensity modulated pelvic radiation therapy in the postoperative treatment of endometrial and cervical cancer. The current project is an updated consensus of CTV definitions, with removal of all references to bony landmarks and inclusion of the para-aortic and inferior obturator nodal regions. An international consensus guideline working group discussed modifications of the current atlas and areas of controversy. A document was prepared to assist in contouring definitions. A sample case abdominopelvic computed tomographic image was made available, on which experts contoured targets. Targets were analyzed for consistency of delineation using an expectation-maximization algorithm for simultaneous truth and performance level estimation with kappa statistics as a measure of agreement between observers. Sixteen participants provided 13 sets of contours. Participants were asked to provide separate contours of the following areas: vaginal cuff, obturator, internal iliac, external iliac, presacral, common iliac, and para-aortic regions. There was substantial agreement for the common iliac region (sensitivity 0.71, specificity 0.981, kappa 0.64), moderate agreement in the external iliac, para-aortic, internal iliac and vaginal cuff regions (sensitivity 0.66, 0.74, 0.62, 0.59; specificity 0.989, 0.966, 0.986, 0.976; kappa 0.60, 0.58, 0.52, 0.47, respectively), and fair agreement in the presacral and obturator regions (sensitivity 0.55, 0.35; specificity 0.986, 0.988; kappa 0.36, 0.21, respectively). A 95% agreement contour was smoothed and a final contour atlas was produced according to consensus. Agreement among the participants was most consistent in the common iliac region and least in the presacral and obturator nodal regions. The consensus volumes formed the basis of the updated NRG/RTOG Oncology postoperative atlas. Continued patterns of recurrence research are encouraged to refine these volumes.
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影响因子：
7.2
作者：
Hoffman, MS;Parsons, M;Cavanagh, D
通讯作者：
Cavanagh, D
DOI：
10.1016/s1470-2045(18)30079-2
发表时间：
2018-03
期刊：
The Lancet. Oncology
影响因子：
--
作者：
de Boer SM;Powell ME;Mileshkin L;Katsaros D;Bessette P;Haie-Meder C;Ottevanger PB;Ledermann JA;Khaw P;Colombo A;Fyles A;Baron MH;Jürgenliemk-Schulz IM;Kitchener HC;Nijman HW;Wilson G;Brooks S;Carinelli S;Provencher D;Hanzen C;Lutgens LCHW;Smit VTHBM;Singh N;Do V;D'Amico R;Nout RA;Feeney A;Verhoeven-Adema KW;Putter H;Creutzberg CL;PORTEC study group
通讯作者：
PORTEC study group
影响因子：
4.7
作者：
Heron, DE;Gerszten, K;Kalnicki, S
通讯作者：
Kalnicki, S
影响因子：
5.7
作者：
Harkenrider, Matthew M.;Adams, William;Grover, Surbhi
通讯作者：
Grover, Surbhi
影响因子：
168.9
作者：
Blake, P.;Swart, Ann Marie;Orton, J.;Kitchener, H.;Whelan, T.;Lukka, H.;Eisenhauer, E.;Bacon, M.;Tu, D.;Parmar, M. K. B.;Amos, C.;Murray, C.;Qian, W.
通讯作者：
Qian, W.