Information Propagation in Time through Allosteric Signaling
Information Propagation in Time through Allosteric Signaling
复制标题
DOI：
10.1103/physrevresearch.2.023367
复制
发表时间：
2019-07
影响因子：
3.4
通讯作者：
T. Modi;S. Ozkan;S. Press'e
中科院分区：
文献类型：
--
作者：
T. Modi;S. Ozkan;S. Press'e
天真地，人们期望由酶嵌入的信号网络下游的酶传递的信息随着酶的产物形成速率单调增长。然而，在这里我们观察到，这并不一定适用于信号网络中经常观察到的变构调节酶。特别是，我们发现变构调节酶的催化位点和信号通路下游接收蛋白之间的相互信息取决于酶的不同变构调节状态之间的转变动力学及其各自的产物形成速率。令人惊讶的是，我们的工作表明，酶产物形成速率的变构下调可能不仅可以用作使自身沉默的一种方式，正如人们通常所期望的那样。相反，下调也可用于增加该酶向信号传导途径下游的受体蛋白传达的信息。
Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which the enzyme is embedded, to grow monotonically with the enzyme's rate of product formation. However, here we observe that this does not necessarily hold true for allosterically regulated enzymes, often observed in signaling networks. In particular, we find that the mutual information between the catalytic sites of an allosterically regulated enzyme and a receiver protein downstream in the signaling pathway depends on the transition kinetics between the different allosterically regulated states of the enzyme and their respective rates of product formation. Surprisingly, our work implies that allosteric down-regulation of an enzyme's rate of product formation may not only be used as a way to silence itself, as one would normally expect. Rather, down-regulation may also be used to increase the information communicated by this enzyme to a receiver protein downstream in a signaling pathway.