Solvent-free 1,3-dipolar cycloaddition of azomethine imines with terminal alkynes promoted by calcium fluoride under the ball milling condition
Solvent-free 1,3-dipolar cycloaddition of azomethine imines with terminal alkynes promoted by calcium fluoride under the ball milling condition
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DOI：
10.1007/s40242-015-4480-0
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发表时间：
2015-06
影响因子：
3.1
通讯作者：
Xiang-Long Chen;Chunman Jia;Li Cao;D. Zhang;Shuixiang Liu;Qi Zhang
中科院分区：
文献类型：
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作者：
Xiang-Long Chen;Chunman Jia;Li Cao;D. Zhang;Shuixiang Liu;Qi Zhang
在无溶剂的球磨条件下，以氟化钙为催化剂，以铜(I)盐为催化剂，偶氮甲碱亚胺与末端炔烃反应，建立了一种方便、高效的合成N,N-双环吡唑烷酮衍生物的方法。环化反应表现出中等至高产率。
A convenient and efficient procedure for the synthesis ofN,N-bicyclic pyrazolidinone derivatives has been developedviathe reaction of azomethine imines with terminal alkynes under the ball milling condition without solvent, which was promoted by calcium fluoride with a catalyst of copper(I) salt. The cyclization reactions exhibited moderate to high yields.