Natural killer cell lines in tumor immunotherapy.
Natural killer cell lines in tumor immunotherapy.
复制标题
自然杀伤细胞系在肿瘤免疫治疗中的应用
DOI：
10.1007/s11684-012-0177-7
复制
发表时间：
2012-03-01
影响因子：
8.1
通讯作者：
Tian, Zhigang
中科院分区：
文献类型：
--
作者：
Cheng, Min;Zhang, Jian;Tian, Zhigang
自然杀伤（NK）细胞被认为是抗癌免疫的关键参与者。然而，癌症能够形成逃避NK细胞攻击或诱导缺陷NK细胞的机制。目前基于NK细胞的癌症免疫疗法旨在通过几种潜在的方法克服NK细胞麻痹，包括激活自体NK细胞、扩增同种异体NK细胞、使用稳定的同种异体NK细胞系以及遗传修饰新鲜NK细胞或NK细胞系。稳定的同种异体NK细胞系方法对于质量控制和大规模生产更实用。此外，通过增加其细胞因子的表达和工程化嵌合肿瘤抗原受体来遗传修饰NK细胞系可以提高其特异性和细胞毒性。本文综述了NK细胞在肿瘤免疫治疗中的应用，并对目前正在进行的几种肿瘤的临床前和临床试验中的治疗性NK细胞系进行了综述。
Natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells. Current NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potential approaches, including activating autologous NK cells, expanding allogeneic NK cells, usage of stable allogeneic NK cell lines and genetically modifying fresh NK cells or NK cell lines. The stable allogeneic NK cell line approach is more practical for quality-control and large-scale production. Additionally, genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumor antigen receptors could improve their specificity and cytotoxicity. In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines currently undergoing preclinical and clinical trials of several kinds of tumors are reviewed.