Functions of circular RNAs in bladder, prostate and renal cell cancer (Review).
Functions of circular RNAs in bladder, prostate and renal cell cancer (Review).
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DOI：
10.3892/mmr.2021.11946
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发表时间：
2021-05
影响因子：
3.4
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Yang L;Zou X;Zou J;Zhang G
环状RNA（CircRNA）是一类通过反向剪接和外显子跳跃形成共价闭合环的非编码RNA。circRNA已被证实在各种生物学功能中起着至关重要的作用，充当microRNA海绵和储库，以及在多种癌症类型的进展过程中与RNA结合蛋白结合。因此，本综述评估了PubMed上2017年11月至2020年9月期间发表的最新研究文章。关键词检索字符串包括："环状RNA（circRNA）和膀胱癌（BC癌）"、"环状RNA（circRNA）和前列腺癌（PCa）"和"环状RNA（circRNA）和肾细胞癌（RCC癌）"。总共发现> 58种circRNA与泌尿系统癌症有关，其中几种circRNA靶向常见的致癌途径，如AKT、TGF-β、MAPK、VEGF甚至代谢途径。circRNA是BC、PCa和RCC的重要调节剂。circRNA在功能上涉及这些癌症类型的发病机制，并且已经发现其作为泌尿系统癌症的诊断和预后的生物标志物。然而，据我们所知，circRNA在泌尿系统肿瘤中的功能在很大程度上仍然未知，需要进一步研究。
Circular RNAs (circRNAs) are a class of non-coding RNAs formed by covalently closed loops through back-splicing and exon-skipping. circRNAs have been confirmed to play a vital role in various biological functions, acting as microRNA sponges and reservoirs, as well as combining with RNA-binding proteins during the progression of multiple cancer types. Therefore, the present review evaluated recent research articles in PubMed that were published between November 2017 and September 2020. Key word search strings included: ‘Circular RNA (circRNA) AND bladder cancer (BC)’, ‘circular RNA (circRNA) AND prostate cancer (PCa)’ and ‘circular RNA (circRNA) AND renal cell cancer (RCC)’. In total, >58 circRNAs were found to be implicated in urological cancers, with several of the circRNAs targeting common carcinogenic pathways, such as the AKT, TGF-β, MAPK, VEGF and even metabolic pathways. circRNAs are important modulators of BC, PCa and RCC. circRNAs are functionally implicated in the pathogenesis of these cancer types, and have been found to act as biomarkers for the diagnosis and prognosis of urological cancer. However, to the best of our knowledge, the functions of circRNAs in tumors of the urinary system remain largely unknown and require further research.