Aiding and abetting roles of NOX oxidases in cellular transformation.

Aiding and abetting roles of NOX oxidases in cellular transformation.
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NOX氧化酶在细胞转化中的帮助和教tong的作用。

DOI:
10.1038/nrc3339
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发表时间:
2012-09
期刊:
Nature reviews. Cancer
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其他
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NADPH氧化酶(NOX)家族的NADPH氧化酶是专门的活性氧生成酶,其广泛且特异性地调节参与癌症发展和进展的氧化还原敏感性信号传导途径。它们通过激活癌基因和灭活肿瘤抑制蛋白作用于特定的细胞膜和微区。在这篇综述中,我们讨论了主要的目标和氧化还原相关的信号系统,受到NOX衍生的ROS,和NOX氧化酶在癌症病因学的生物学作用。
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.
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