DIETARY-CHOLESTEROL AND INCIDENCE OF LUNG-CANCER - THE WESTERN ELECTRIC STUDY
DIETARY-CHOLESTEROL AND INCIDENCE OF LUNG-CANCER - THE WESTERN ELECTRIC STUDY
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DOI：
10.1093/oxfordjournals.aje.a116119
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发表时间：
1991-09-01
影响因子：
5
通讯作者：
STAMLER, J
中科院分区：
文献类型：
--
作者：
SHEKELLE, RB;ROSSOF, AH;STAMLER, J
一项为期 24 年的队列研究对膳食胆固醇与肺癌呈正相关这一假设进行了调查，研究对象为 1,878 名 1958 年在芝加哥西部电气公司工作的中年男性。 调整香烟、年龄、β-胡萝卜素和脂肪的摄入量后，与膳食胆固醇增加 500 毫克/天相关的肺癌相对风险为 1.9（95% 置信区间 1.1-3.4）。 结果表明，这种关联特定于鸡蛋中的胆固醇。 需要进一步的研究来了解这种关联的基础。
The hypothesis that dietary cholesterol is positively associated with lung cancer was investigated in a 24-year cohort study of 1,878 middle-aged men who were employed in 1958 by the Western Electric Company in Chicago. The relative risk of lung cancer associated with an increment in dietary cholesterol of 500 mg/day was 1.9 (95 percent confidence interval 1.1-3.4) after adjustment for cigarettes, age, and intake of beta-carotene and fat. Results suggested that the association was specific to cholesterol from eggs. Further research is needed to understand the basis for this association.