Correlating notch signaling with thymocyte maturation
Correlating notch signaling with thymocyte maturation
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DOI：
10.1016/s1074-7613(00)80643-3
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发表时间：
1998-12-01
期刊：
影响因子：
32.4
通讯作者：
Bevan, MJ
中科院分区：
文献类型：
--
作者：
Deftos, ML;He, YW;Bevan, MJ
Notch受体及其配体参与多种发育过程。它们在胸腺中高度表达，并与CD4和CD8谱系的决定有关。我们鉴定了小鼠Notch-1的细胞内活性片段能够使胸腺瘤抵抗糖皮质激素诱导的细胞凋亡。这一效应在其他T细胞系和CD4(+)CD8(+)DP胸腺细胞中得到证实。Notch信号通路的激活也上调了其他一些标记物的表达，这些标记物与类固醇耐药一样，与DP成熟到CD4和CD8谱系有关。这些结果表明，Notch信号在DP胸腺细胞成熟为CD4(+)和CD8(+)SP胸腺细胞过程中起关键作用。
The Notch receptor and its ligands are involved in many developmental processes. They are highly expressed in the thymus and have been implicated in the CD4 versus CD8 lineage decision. We identified the constitutively active intracellular fragment of murine Notch-1 as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis. This effect was confirmed in other T cell lines and in CD4(+)CD8(+) DP thymocytes. Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages. These results suggest that Notch signaling is critically involved in the maturation of DP thymocytes into both CD4(+) and CD8(+) SP thymocytes.