Fetal scarless wound healing.
Fetal scarless wound healing.
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发表时间：
1999-10
期刊：
影响因子：
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通讯作者：
P. Samuels;A. K. Tan
中科院分区：
文献类型：
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作者：
P. Samuels;A. K. Tan
胎儿监护和胎儿开放手术治疗危及生命的先天性疾病的进展为我们提供了独特的机会，检查胎儿手术伤口愈合。胎儿的伤口愈合迅速，不留疤痕。胎儿无瘢痕愈合的确切机制仍不清楚。本文通过研究胎儿皮肤、胎儿成纤维细胞、伤口基质、胎儿环境和各种细胞因子的内在特性，说明了对胎儿伤口愈合过程的最新认识。在胎儿伤口中，转化生长因子-β和富含透明质酸的伤口基质在无瘢痕修复中起关键作用。不同的实验策略来操纵成人伤口的愈合将被提出。这些治疗措施是基于无瘢痕胎儿伤口修复模型。我们还将简要地评论胎儿手术的现状。
Advances in fetal monitoring and open fetal surgery for life-threatening congenital diseases have provided us with the unique opportunity to examine fetal surgical wound healing. Fetal wounds heal rapidly and without scarring. The exact mechanisms of fetal scarless healing remain unknown. This article illustrates the most current understanding of the fetal wound healing process by examining the intrinsic properties of fetal skin, fetal fibroblasts, wound matrix, fetal environment, and various cytokines. In fetal wound, transforming growth factor-beta and hyaluronic acid-rich wound matrix play pivoting roles in scarless repair. Different experimental strategies to manipulate the healing of adult wounds will be presented. These therapeutic measures are based on the scarless fetal wound repair model. We will also briefly comment on the current status of fetal surgery.