Parturitions, menopause and other physiological stressors are recorded in dental cementum microstructure
Parturitions, menopause and other physiological stressors are recorded in dental cementum microstructure
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DOI：
10.1038/s41598-020-62177-7
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发表时间：
2020-03-25
影响因子：
4.6
通讯作者：
Bromage, Timothy G.
中科院分区：
文献类型：
--
作者：
Cerrito, Paola;Bailey, Shara E.;Bromage, Timothy G.
近代人类的生活史模式在许多方面都是独一无二的，包括生殖后寿命的延长和生育间隔的缩短。人们提出了许多理论来解释这种不寻常模式的演变。然而，由于古人类化石记录的残缺不全，以及缺乏能够推断这种后期生活史事件的方法，大多数理论都难以验证。为了寻找一种方法，我们测试了分娩和更年期的生理影响事件记录在牙骨质微观结构的假设。我们对来自15个已知生活史事件的个体的47颗牙齿进行了组织形态学分析，并能够检测到所有女性的生殖事件和更年期。此外，我们发现其他压力事件，如系统性疾病和监禁也可以检测到。最后，通过开发一种新的分析方法，我们能够以高精度（r²=0.92）对所有这些事件进行计时。
The life history pattern of recent humans is uniquely derived in many of its aspects including an extended post-reproductive lifespan combined with short interbirth intervals. A number of theories have been proposed to explain the evolution of this unusual pattern. However most have been difficult to test due to the fragmentary nature of the hominin fossil record and the lack of methods capable of inferring such later life history events. In search of a method we tested the hypothesis that the physiologically impactful events of parturition and menopause are recorded in dental cementum microstructure. We performed histomorphological analyses of 47 teeth from 15 individuals with known life history events and were able to detect reproductive events and menopause in all females. Furthermore, we found that other stressful events such as systemic illnesses and incarceration are also detectable. Finally, through the development of a novel analytical method we were able to time all such events with high accuracy (R-squared=0.92).