Human Herpesvirus 6 Infection of the Central Nervous System.
Human Herpesvirus 6 Infection of the Central Nervous System.
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DOI：
10.1007/s11908-004-0054-x
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发表时间：
2004-08-01
影响因子：
3.1
通讯作者：
Caserta, Mary T.
中科院分区：
文献类型：
--
作者：
Caserta, Mary T.
人类疱疹病毒（HHV）6感染所有儿童，通常在生命的第一年。高热是原发性感染的标志，热性惊厥是最常见的并发症。初次感染后，HHV-6在多个部位保持潜伏或持续，并有间歇性再激活。中枢神经系统（CNS）的许多病症已与HHV-6再活化相关，包括慢性癫痫发作病症、脑炎和脱髓鞘病症（包括多发性硬化症）。尽管多项研究已经拼凑出了对HHV-6的分子组织、病毒特征、免疫学和流行病学的理解，但这种病毒在CNS疾病中的真正作用仍在展开。
Human herpesvirus (HHV) 6 infects all children, usually during the first year of life. High fever is the hallmark of primary infection, with febrile seizures the most common complication. After primary infection, HHV-6 remains latent or persistent at multiple sites, with intermittent reactivation. Many disorders of the central nervous system (CNS) have been linked to HHV-6 reactivation, including chronic seizure disorders, encephalitis, and demyelinating disorders including multiple sclerosis. Although multiple studies have pieced together an understanding of the molecular organization, viral characteristics, immunology, and epidemiology of HHV-6, the true role of this virus in diseases of the CNS is still unfolding.