The Synthesis and Bioactivities of 2-Hydroxyethyl Benzo[d] Isothiazole-3(2H)-One Marine Antifouling Paints
The Synthesis and Bioactivities of 2-Hydroxyethyl Benzo[d] Isothiazole-3(2H)-One Marine Antifouling Paints
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DOI：
10.4028/www.scientific.net/amr.646.24
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发表时间：
2013-01
期刊：
影响因子：
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通讯作者：
Jian Xin Yang;Chenghang You;Xiang-hui Wang;Q. Lin
中科院分区：
文献类型：
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作者：
Jian Xin Yang;Chenghang You;Xiang-hui Wang;Q. Lin
以苯并[d]异噻唑-3(2H)- 1和芳香酸为原料合成了21个新化合物，并通过1H NMR、IR、EA等手段对其结构进行了鉴定。采用引入抗菌实验对其抗菌活性进行了评价，并采用海洋挂板实验对其对海洋污染生物的活性进行了评价。结果表明，所有化合物对6种细菌均有抑制作用，在浓度为32µg/ml时，对革兰氏阳性细菌的抑制率为90%，防污漆在海洋环境中不能被海洋污染生物附着3个月以上。
Twenty-one novel compounds were synthesized from the benzo[d]isothiazole-3(2H)-one and aromatic acid, the structures were identified by means of 1H NMR, IR, EA. The intro antibacterial experiment was carried out to evaluate the activities against antibacterial and the marine hanging plate experiment was also carried out to evaluate the activities against marine fouling organism. The results showed that all the compounds were active against the six bacterials, with an inhibiting rate of 90% at the concentration of 32 µg/ml against Gram-positive bacterials, and the antifouling paints couldn’t be attached by marine fouling organisms in the marine environment for more than 3 months.