Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: A retrospective single-center analysis of 72 cases
Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: A retrospective single-center analysis of 72 cases
复制标题
原发性唾液腺粘膜相关淋巴组织淋巴瘤的临床病理学：72例单中心回顾性分析
DOI：
10.1111/jop.13168
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发表时间：
2021-03-29
影响因子：
3.3
通讯作者：
Li, Jiang
中科院分区：
文献类型：
--
作者：
Zhang, Chunye;Xia, Ronghui;Li, Jiang
涎腺结外边缘区淋巴瘤是一种罕见的粘膜相关淋巴组织淋巴瘤（MALT淋巴瘤），尚未得到广泛的研究。我们旨在探讨涎腺MALT淋巴瘤的临床病理特征和分子变化。方法对72例有临床病理资料的原发性涎腺MALT淋巴瘤进行分析。采用间期荧光原位杂交（FISH）检测MALT1基因易位、3、18三体。采用SPSS 17.0软件包对数据进行分析。结果男女比例为1:8 .8，中位年龄为57.0岁。12.5%（9/72）患者出现多发肿胀。单发肿块中以腮腺最常见（47/63,74.6%），其次为上颚（7/63,11.1%）。34.7%的患者有自身免疫性疾病，其中干燥综合征（SS）最为常见。在成功手术的70例患者中，3三体是最常见的分子改变（41/70,58.6%），其次是18三体（7/70,10%）和MALT1易位（5/70,7.1%）。无SS患者的肿瘤组织倾向于表现为3三体（p = 0.038）。5年总生存率为94.1%，5年无病生存率为85.3%（平均随访104.7个月）。无SS和18三体的患者无复发生存期延长（p = 0.015, p = 0.001）。结论唾液腺MALT淋巴瘤与自身免疫性疾病相关，3三体是最常见的遗传改变。18三体可以用来预测肿瘤复发的可能性。
Background Salivary gland extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) is uncommon and has not been studied extensively. We aimed to investigate the features of clinicopathological and molecular changes of salivary MALT lymphoma.Methods Seventy-two cases of primary salivary MALT lymphoma that had clinicopathological information available were utilized in this study. MALT1 gene translocation, trisomy 3, and trisomy 18 were detected by interphase fluorescence in situ hybridization (FISH). The data were analyzed using SPSS 17.0 software package.Results The ratio of male to female was 1:2.8, and the median age was 57.0 years. 12.5% (9/72) of the patients presented with multiple swellings. Among the others with solitary mass, the parotid gland was involved most frequently (47/63,74.6%), followed by the palate (7/63, 11.1%). 34.7% of patients had an autoimmune disease, with Sjogren syndrome (SS) being the most common. Among the 70 cases successfully performed, it was identified that trisomy 3 was the most frequent molecular change (41/70, 58.6%), followed by trisomy 18 (7/70, 10%) and MALT1 translocation (5/70, 7.1%). The tumor tissue tended to exhibit trisomy 3 in patients without SS (p = 0.038). The 5-year overall survival was 94.1%, and the 5-year disease-free survival was 85.3% (mean follow-up time: 104.7 months). The patients without SS and trisomy 18 had a prolonged recurrence-free survival (p = 0.015, p = 0.001 respectively).Conclusion Salivary gland MALT lymphoma is associated with autoimmune diseases, and trisomy 3 is the most common genetic change. Trisomy 18 can be used to predict the possibility of tumor relapse.