Reward-related decision-making in pediatric major depressive disorder: an fMRI study
Reward-related decision-making in pediatric major depressive disorder: an fMRI study
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DOI：
10.1111/j.1469-7610.2006.01673.x
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发表时间：
2006-10-01
影响因子：
7.6
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
--
作者：
Forbes, Erika E.;May, J. Christopher;Dahl, Ronald E.
背景：尽管奖励处理被认为是情感功能的重要组成部分，但很少有研究调查情感障碍青少年的奖励相关决策或反应。抑郁症被认为与奖励相关的情感系统活动减少有关。方法：使用功能磁共振成像（fMRI），我们通过奖励决策任务研究了青少年抑郁症患者对奖励的行为和神经反应。这项任务包括选择可能的奖励，包括不同程度和概率的奖励。研究设计允许奖励处理的决定/预期和结果阶段的分离。参与者年龄在9-17岁之间，被诊断为重度抑郁症（MDD）、焦虑症或无精神疾病史。结果：在任务的两个阶段，重度抑郁症参与者在与奖励相关的大脑区域表现出比对照组参与者更少的神经反应。群体差异似乎并不是焦虑的结果。抑郁和焦虑症状与大脑奖励相关区域的激活有关。结论：研究结果表明，抑郁症涉及奖励加工的改变，并强调了进一步研究发展、情感障碍和奖励加工之间关系的必要性。
Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.