Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in Sprague Dawley rats
Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in Sprague Dawley rats
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DOI：
10.1055/s-2006-957630
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发表时间：
1997-04-01
期刊：
影响因子：
2.7
通讯作者：
Roh, JK
中科院分区：
文献类型：
--
作者：
Jeong, TC;Kim, HJ;Roh, JK
在雄性 Sprague Dawley 大鼠中研究了红参皂苷对四氯化碳引起的肝毒性的保护作用。本研究使用以人参皂苷-Rb1、-Rb2、-Rc、-Rd、-Re 和-Rg1 标准化的红参总皂苷。连续7天口服标准化红参皂苷50、100和200mg/kg，然后腹腔注射0.4ml/kg四氯化碳玉米油溶液24h。施用皂苷既不改变体重和器官重量，也不改变血液学和血清临床参数。由四氯化碳引起的SGPT和SGOT活性的升高通过给予皂苷而部分恢复。根据组织学检查，红参皂苷清楚地恢复了四氯化碳引起的肝脏空泡化和淋巴样细胞聚集。目前的结果表明，这些研究中使用的标准化红参皂苷可以部分恢复四氯化碳对雄性斯普拉格道利大鼠引起的肝毒性。
The protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity were investigated in male Sprague Dawley rats. The total saponins of red ginseng standardized on ginsenosides-Rb1, -Rb2, -Rc, -Rd, -Re, and -Rg1 were used in the present study. The rats were administered the standardized saponins of red ginseng orally at 50, 100, and 200 mg/kg for 7 consecutive days, followed by an administration of carbon tetrachloride at 0.4 ml/kg in corn oil intraperitoneally for 24h. The administration of saponin changed neither body and organ weights nor hematological and serum clinical parameters. The elevation of SGPT and SGOT activities induced by carbon tetrachloride was partially recovered by the administration of the saponin. The liver vacuolization and lymphoid cell aggregation by carbon tetrachloride were clearly recovered by the red ginseng saponins as examined histologically. The present results indicated that the standardized saponins of red ginseng used in these studies may partially recover the hepatotoxicity induced by carbon tetrachloride in male Sprague Dawley rats.