Developing guinea pig brain as a model for cortical folding
Developing guinea pig brain as a model for cortical folding
复制标题
DOI：
10.1111/dgd.12371
复制
发表时间：
2017-05-01
影响因子：
2.5
通讯作者：
Shimamura, Kenji
中科院分区：
文献类型：
--
作者：
Hatakeyama, Jun;Sato, Haruka;Shimamura, Kenji
哺乳动物的大脑皮层，特别是新皮层，在其大小和形态方面在物种之间具有高度多样性，这可能反映了这一谱系的巨大适应性。特别是，在皮层表面上的回旋脊和裂缝（分别称为脑回和脑沟）的模式和数量在物种甚至个体之间是可变的。然而，很少有人知道皮质折叠的机制，虽然已经提出了几个假设。最近对胚胎神经发生的研究表明，皮层祖细胞的差异是脑回化过程中的一个关键因素。在这里，我们研究了脑回的过程中使用发展中的豚鼠大脑，形成一个简单的，但基本的模式回。此外，我们还建立了电穿孔介导的豚鼠胚胎基因转移方法。我们介绍了豚鼠脑作为一个有用的模型系统，以了解皮质折叠的机制和基本原理。
The cerebral cortex in mammals, the neocortex specifically, is highly diverse among species with respect to its size and morphology, likely reflecting the immense adaptiveness of this lineage. In particular, the pattern and number of convoluted ridges and fissures, called gyri and sulci, respectively, on the surface of the cortex are variable among species and even individuals. However, little is known about the mechanism of cortical folding, although there have been several hypotheses proposed. Recent studies on embryonic neurogenesis revealed the differences in cortical progenitors as a critical factor of the process of gyrification. Here, we investigated the gyrification processes using developing guinea pig brains that form a simple but fundamental pattern of gyri. In addition, we established an electroporation-mediated gene transfer method for guinea pig embryos. We introduce the guinea pig brain as a useful model system to understand the mechanisms and basic principle of cortical folding.