Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties.

Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties.
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具有受控机械性能的酶降解肝素聚乙二醇凝胶。

DOI:
10.1039/b921616b
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发表时间:
2010
影响因子:
4.9
通讯作者:
C. Werner
C. Werner
中科院分区:
化学2区
文献类型:
--
作者:
M. Tsurkan;K. Levental;U. Freudenberg;C. Werner

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通过将聚乙二醇、肝素和基质金属蛋白酶可裂解的肽序列组合成明确的水凝胶网络,制备了一类新型可生物降解材料,该水凝胶网络模仿天然细胞外基质,提供机械支撑和化学信号,并引发动态相互响应。
A new class of biodegradable materials was prepared by combining polyethylene glycol, heparin, and a matrix metalloproteinase-cleavable peptide sequence into a well-defined hydrogel network which mimics native extracellular matrices in its ability to provide mechanical support and chemical signals as well as elicit a dynamic reciprocal response.
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发表时间: 2007-03-21
影响因子: 15
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