Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla
Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla
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DOI：
10.1111/eos.12092
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发表时间：
2013-12-01
影响因子：
1.9
通讯作者：
Kiliaridis, Stavros
中科院分区：
文献类型：
--
作者：
Denes, Balazs J.;Mavropoulos, Anestis;Kiliaridis, Stavros
以往的研究表明，咀嚼功能的完全缺失会导致牙槽突和牙周膜变窄。本研究的目的是探讨，第一次，牙槽突和牙周膜在咀嚼功能减退。26只大鼠，3周龄，随机分为硬或软饮食组（n = 13每组）。6周后处死大鼠，用微型计算机断层扫描（micro-CT）扫描其颅骨。我们测量了PDL所占空间的横截面宽度，以及横截面牙槽窝表面（AS）和横截面牙根表面（RS）。我们还测量了牙槽突的宽度。与喂食硬饲料的大鼠相比，喂食软饲料的大鼠的肺泡突更窄，PDL宽度更薄，AS更小。牙周膜宽度与牙槽突宽度、AS相关。在喂食软食的大鼠中发现的较窄的牙槽突是牙槽骨和PDL改变的结果。它们之间的相关性提供了证据表明，咬合负荷的减少会引起两种组织的同时反应。
Previous studies have established that complete absence of masticatory function results in a narrower alveolar process and periodontal ligament (PDL). The aim of our study was to investigate, for the first time, both the alveolar process and the PDL in masticatory hypofunction. Twenty-six rats, 3 wk of age, were randomly assigned to either a hard-or a soft-diet group (n = 13 each group). The rats were killed after 6 wk and their skulls were scanned using micro-computed tomography (micro-CT). We measured the cross-sectional width of the space occupied by the PDL, as well as the cross-sectional alveolar socket surface (AS) and the cross-sectional root surface (RS). We also measured the width of the alveolar process. The alveolar process was narrower, the PDL width was thinner, and the AS was smaller in rats fed a soft diet compared with rats fed a hard diet. The PDL width was correlated to the alveolar process width and the AS. The narrower alveolar process found in rats fed a soft diet is the result of alterations to both the alveolar bone and the PDL. The correlation between them provides evidence that a reduction of occlusal loading induces a simultaneous response in both tissues.