Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
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DOI：
10.7554/elife.04363
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发表时间：
2015-02-25
期刊：
影响因子：
7.7
通讯作者：
Reproducibility Project Cancer Biology
中科院分区：
文献类型：
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作者：
Chroscinski D;Sampey D;Maherali N;Reproducibility Project: Cancer Biology;Reproducibility Project Cancer Biology
生殖项目：癌症生物学旨在通过对2010年至2012年期间发表的50篇癌症生物学领域的论文进行复制，来解决人们对科学研究中可重复性日益增长的担忧。这份注册报告描述了Ricci-Vitiani及其同事2010年发表在《自然》杂志上的“通过胶质母细胞瘤干细胞样细胞的内皮分化实现肿瘤血管化”关键实验的拟议复制计划。将重复的实验是图4 B和补充图10 B中报道的那些，其证明成胶质细胞瘤干细胞样细胞可以衍生为内皮细胞，并且可以被选择性消融以减少体内肿瘤进展，以及补充图S10 C和S10 D，其证明完全分化的成胶质细胞瘤细胞不能形成功能相关的内皮。生殖项目：癌症生物学是开放科学中心和科学交流中心之间的合作，复制结果将由eLife发布。DOI：http://dx.doi.org/10.7554/eLife.04363.001网站
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from ‘Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells’ by Ricci-Vitiani and colleagues, published in Nature in 2010. The experiments that will be replicated are those reported in Figure 4B and Supplementary Figure 10B, which demonstrate that glioblastoma stem-like cells can derive into endothelial cells, and can be selectively ablated to reduce tumor progression in vivo, and Supplementary Figures S10C and S10D, which demonstrate that fully differentiated glioblastoma cells cannot form functionally relevant endothelium. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife. DOI: http://dx.doi.org/10.7554/eLife.04363.001