The diagnosis of young-onset dementia.
The diagnosis of young-onset dementia.
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DOI：
10.1016/s1474-4422(10)70159-9
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发表时间：
2010-08
期刊：
影响因子：
48
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Rossor, Martin N.;Fox, Nick C.;Mummery, Catherine J.;Schott, Jonathan M.;Warren, Jason D.
痴呆症的诊断在任何年龄都是毁灭性的，但对年轻患者的诊断是一个特别的挑战。这种鉴别诊断是广泛的，因为代谢性疾病的晚期表现很常见，而且这些患者中遗传性痴呆的负担比晚发型痴呆患者更高。晚年常见的退行性疾病，如阿尔茨海默氏病，在第五或六十年出现时可能会有所不同。此外，许多年轻发病的痴呆症是可以治疗的。对许多遗传性退行性痴呆的致病基因的鉴定导致了对分子病理学的理解，这也适用于晚发的散发性疾病。这一理解为未来的治疗提供了根据年轻和晚发性痴呆的具体诊断量身定做的可能性。
A diagnosis of dementia is devastating at any age but diagnosis in younger patients presents a particular challenge. The differential diagnosis is broad as late presentation of metabolic disease is common and the burden of inherited dementia is higher in these patients than in patients with late-onset dementia. The presentation of the common degenerative diseases of late life, such as Alzheimer's disease, can be different when presenting in the fifth or sixth decade. Moreover, many of the young-onset dementias are treatable. The identification of causative genes for many of the inherited degenerative dementias has led to an understanding of the molecular pathology, which is also applicable to later-onset sporadic disease. This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia.