Functional specificity of claustrum connections in the rat: interhemispheric communication between specific parts of motor cortex.
Functional specificity of claustrum connections in the rat: interhemispheric communication between specific parts of motor cortex.
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DOI：
10.1523/jneurosci.4438-10.2010
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发表时间：
2010-12-15
期刊：
影响因子：
--
通讯作者：
Alloway KD
中科院分区：
文献类型：
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作者：
Smith JB;Alloway KD
最近的证据表明，大鼠屏状体连接两个半球的运动皮质区。为了阐明屏状核和初级运动（MI）皮质之间的半球间连接的功能特异性，在MI的特定部位进行顺行示踪剂注射与在对侧半球的同位置部位进行逆行示踪剂注射配对。除了在两个半球注射MI前爪（Fp）区域外，我们还注射了与胡须收缩（Re）相关的区域和更接近尾部的节律性拂动（RW）区域。虽然MI-Fp区域与任一半球的屏状体几乎没有连接，但两个晶须区域都投射到对侧屏状体，其中来自MI-RW区域的晶须区域比来自MI-Re区域的晶须区域更密集且更广泛。逆行示踪剂注射在MI-RW区域产生更多的标记神经元在同侧屏状体比逆行示踪剂注射在MI-Re。与这些模式相一致，标记的终端和索马在屏状体的重叠是最大的两种示踪剂注入到MI-RW区域。当逆行示踪剂注入屏状核时，MI中标记神经元的最高密度出现在对侧RW区。在屏状核中注射示踪剂也发现了数百个标记的神经元，遍及其吻尾侧范围，从而建立了长距离屏状核内连接的存在。这些结果表明，大鼠屏状核的内在和外在连接的结构为快速，interhemispherical传输所需的信息，双边协调的MI地区，调节胡须运动。
Recent evidence indicates that the rat claustrum interconnects the motor cortical areas in both hemispheres. To elucidate the functional specificity of the interhemispheric connections between the claustrum and primary motor (MI) cortex, anterograde tracer injections in specific parts of MI were paired with retrograde tracer injections in homotopic sites of the opposite hemisphere. In addition to injecting the MI forepaw (Fp) region in both hemispheres, we injected the region associated with whisker retractions (Re) and the more caudal rhythmic whisking (RW) region. While the MI-Fp region has few connections with the claustrum of either hemisphere, both whisker regions project to the contralateral claustrum, with those from the MI-RW region being denser and more extensive than those originating from the MI-Re region. Retrograde tracer injections in the MI-RW region produced more labeled neurons in the ipsilateral claustrum than retrograde tracer injections in the MI-Re. Consistent with these patterns, the overlap of labeled terminals and soma in the claustrum was greatest when both tracers were injected into the MI-RW region. When retrograde tracers were injected into the claustrum, the highest density of labeled neurons in MI appeared in the contralateral RW region. Tracer injections in the claustrum also revealed hundreds of labeled neurons throughout its rostrocaudal extent, thereby establishing the presence of long-range intra-claustral connections. These results indicate that the intrinsic and extrinsic connections of the rat claustrum are structured for rapid, interhemispheric transmission of information needed for bilateral coordination of the MI regions that regulate whisker movements.