Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging.
Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging.
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DOI：
10.1161/circimaging.113.001093
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发表时间：
2014-05-01
期刊：
影响因子：
--
通讯作者：
Seo, Hong Seog
中科院分区：
文献类型：
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作者：
Kim, Eung Ju;Kim, Sungeun;Seo, Hong Seog
背景：动脉粥样硬化被认为是一种与造血和免疫相关器官（如骨髓和脾脏）激活相关的炎症性疾病。我们用（18）f -氟脱氧葡萄糖正电子发射断层扫描评估了冠状动脉疾病（包括急性心肌梗死）患者这些器官和颈动脉的代谢活性。方法与结果：对32例急性心肌梗死患者、33例慢性稳定型心绞痛患者和25例对照患者进行全身联合（18）氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描。计算脾脏和腰椎BM感兴趣区域的平均标准摄取值。计算颈动脉和颈静脉标准摄取值的目标背景比。急性心肌梗死患者BM（1.67±0.16）和脾脏（2.57±0.39）的标准摄取值及颈动脉靶本比（2.13±0.42）均显著高于心绞痛患者的相应值(1.22±0.62;2.03±0.35;1.36±0.37
BACKGROUND: Atherosclerosis is considered to be an inflammatory disease associated with the activation of hematopoietic and immune-related organs such as the bone marrow (BM) and spleen. We evaluated the metabolic activity of those organs and of the carotid artery with (18)F-fluorodeoxyglucose positron emission tomography in patients with coronary artery disease, including acute myocardial infarction.METHODS AND RESULTS: Whole-body combined (18)F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 32 patients with acute myocardial infarction, 33 patients with chronic stable angina, and 25 control subjects. The mean standard uptake value was calculated in the regions of interest in the spleen and the BM of lumbar vertebrae. The target-to-background ratio of the standard uptake values of the carotid artery and jugular vein was also calculated. In patients with acute myocardial infarction, the standard uptake values of the BM (1.67±0.16) and spleen (2.57±0.39), as well as the target-to-background ratio of the carotid artery (2.13±0.42), were significantly higher than the corresponding values of patients with angina (1.22±0.62; 2.03±0.35; 1.36±0.37; all P