Selective dopamine D2 receptor reduction enhances a D1-mediated oral dyskinesia in rats.
Selective dopamine D2 receptor reduction enhances a D1-mediated oral dyskinesia in rats.
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DOI：
10.1016/0024-3205(86)90434-0
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发表时间：
1986-07
期刊：
影响因子：
6.1
通讯作者：
H. Rosengarten;J. Schweitzer;A. Friedhoff
中科院分区：
文献类型：
--
作者：
H. Rosengarten;J. Schweitzer;A. Friedhoff
我们以前已经表明，通过使用选择性D1和D2多巴胺受体相互作用的药物，在大鼠重复下颌运动可以通过激活D1系统或D2系统的封锁。在目前的研究中，我们已经表明，遗传或发育因素导致较少的D2-相对于D1-受体与重复的下颌运动。我们发现，在两个品系的大鼠与不同的纹状体D2到D1的比例，应变与较少的D2网站有更多的下颌运动。我们还发现，通过产前干预减少D2受体的实验导致自发下颌运动增加，衰老也是如此，这伴随着D2受体数量的减少。在大鼠中进行的这些研究的结果，在许多方面与人类口腔运动障碍与衰老或抗精神病药物治疗相关的结果平行。
We have previously shown, through the use of selective D1and D2dopamine receptor interactive drugs, that repetitive jaw movements in rats can be produced by activation of the D1system or blockade of the D2system. In the present study we have shown that genetic or developmental factors resulting in a lesser number of D2- relative to D1- receptors is associated with repetitive jaw movements. We have found in two strains of rats with different striatal D2to D1ratios, the strain with fewer D2sites had more jaw movements. We also found that experimental reduction of D2receptors via prenatal intervention resulted in an increase in spontaneous jaw movements, as did aging, which is accompanied by a decrease in the number of D2receptors. The findings of these studies carried out in rats, parallel, in a number of ways, findings in human oral dyskinesia associated with either aging or neuroleptic treatment.