The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy
The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy
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DOI：
10.1016/s0022-510x(02)00279-4
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发表时间：
2003-01-15
影响因子：
4.4
通讯作者：
Osame, M
中科院分区：
文献类型：
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作者：
Kiwaki, T;Umehara, F;Osame, M
我们描述了经腓肠神经活检证实患有周围神经病变的 HTLV-I 相关性脊髓病 (HAM)/热带痉挛性截瘫 (TSP) 患者的临床和病理学研究。 HAM/TSP患者的腓肠神经病理学显示，最常见的病理改变类型是脱髓鞘和髓鞘再生以及轴突变性和再生的组合，并且这种改变因并发症而改变。病理变化与疾病持续时间和 I 型人类 T 淋巴细胞病毒 (HTLV-I) 前病毒载量均不相关。这项研究表明周围神经可能参与 HAM/TSP。 (C) 2002 Elsevier Science B.V. 保留所有权利。
We describe the clinical and pathological studies in HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP) patients with peripheral neuropathy as proven by sural nerve biopsy. Sural nerve pathology in HAM/TSP patients revealed that the most common type of pathologic change is a combination of both demyelination and remyelination and axonal degeneration and regeneration, and this change is modified by the complications. The pathologic changes were correlated with neither the duration of disease nor human T lymphotropic virus type I (HTLV-I) proviral load. This study suggests that peripheral nerves could be involved in HAM/TSP. (C) 2002 Elsevier Science B.V. All rights reserved.