Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity
Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity
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DOI：
10.1128/jvi.74.15.7127-7136.2000
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发表时间：
2000-08-01
影响因子：
5.4
通讯作者：
Steinkasserer, A
中科院分区：
文献类型：
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作者：
Kruse, M;Rosorius, O;Steinkasserer, A
成熟树突状细胞（DC）是整个免疫系统中最有效的抗原呈递细胞。因此，干扰这些细胞的功能构成了病毒逃避免疫反应的一种非常强大的机制。疱疹病毒科的几个成员提供了这样的逃逸策略的例子，包括干扰抗原呈递和产生同源细胞因子，在这项研究中，我们研究了成熟DC感染单纯疱疹病毒1型（HSV-1）和感染的方式改变成熟DC的表型和功能。有趣的是，这些DC的T细胞刺激能力受到强烈损害。此外，我们证明HSV-1导致CD 83的特异性降解，CD 83是一种在DC成熟过程中特异性上调的细胞表面分子。这些数据表明，HSV-1已经开发出另一种逃避免疫反应的新机制。
Mature dendritic cells (DC) are the most potent antigen-presenting cells within the entire immune system. Interference with the function of these cells therefore constitutes a very powerful mechanism for viruses to escape immune responses. Several members of the Herpesviridae family have provided examples of such escape strategies, including interference with antigen presentation and production of homologous cytokines, In this study we investigated the infection of mature DC with herpes simplex virus type 1 (HSV-1) and the way in which infection alters the phenotype and function of mature DC. Interestingly, the T-cell-stimulatory capacity of these DC was strongly impaired, Furthermore, we demonstrated that HSV-1 leads to the specific degradation of CD83, a cell surface molecule which is specifically upregulated during DC maturation. These data indicate that HSV-1 has developed yet another novel mechanism to escape immune responses.