AUTOCRINE REGULATION OF TOXIN SYNTHESIS BY STAPHYLOCOCCUS-AUREUS
AUTOCRINE REGULATION OF TOXIN SYNTHESIS BY STAPHYLOCOCCUS-AUREUS
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DOI：
10.1073/pnas.92.5.1619
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发表时间：
1995-02-28
影响因子：
11.1
通讯作者：
NOVICK, RP
中科院分区：
文献类型：
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作者：
BALABAN, N;NOVICK, RP
金黄色葡萄球菌是引起从轻微皮肤感染到心内膜炎和中毒性休克综合征的疾病的主要人类病原体。对S.金黄色葡萄球菌主要是由于产生毒性外蛋白，其合成受全球调节系统AGR控制。我们在这里表明，agr是由细菌产生和分泌的蛋白质因子自诱导的，并且它被外蛋白缺陷的S.金黄色葡萄球菌突变株。抑制剂RIP与激活剂RAP竞争，并且可能是突变衍生物。我们的研究结果提出了两种可能的方法，独立于抗生素，以控制S。金黄色葡萄球菌感染。RIP可能被证明是有用的，作为一种直接抑制剂的毒力和RAP作为一种疫苗，对agr诱导的毒力因子的表达，无论是可以干扰的细菌建立和维持感染的能力。
Staphylococcus aureus is a major human pathogen causing diseases which range from minor skin infection to endocarditis and toxic shock syndrome. The pathogenesis of S. aureus is due primarily to the production of toxic exoproteins, whose synthesis is controlled by a global regulatory system, agr. We show here that agr is autoinduced by a proteinaceous factor produced and secreted by the bacteria and that it is inhibited by a peptide produced by an exoprotein-deficient S. aureus mutant strain. The inhibitor, RIP, competes with the activator, RAP, and may be a mutational derivative. Our results suggest two possible approaches, independent of antibiotics, to the control of S. aureus infections. RIP may prove useful as a direct inhibitor of virulence and RAP as a vaccine against the expression of agr-induced virulence factors; either could interfere with the ability of the bacteria to establish and maintain an infection.