The neural mechanisms underlying the influence of Pavlovian cues on human decision making
The neural mechanisms underlying the influence of Pavlovian cues on human decision making
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DOI：
10.1523/jneurosci.0897-08.2008
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发表时间：
2008-05-28
影响因子：
5.3
通讯作者：
O'Doherty, John P.
中科院分区：
文献类型：
--
作者：
Bray, Signe;Rangel, Antonio;O'Doherty, John P.
在结果特异性迁移中，巴甫洛夫线索预测特定结果会使行为选择偏向于与这些结果相关的行为。尽管在巴甫洛夫线索的存在下没有明确的工具性动作训练，这种转移还是发生了。这种效应在人类中的神经基质尚不清楚。为了解决这个问题，我们用功能性磁共振成像扫描了23名人类受试者，同时他们在先前与这些结果之一相关的巴甫洛夫线索存在的情况下，在不同的液体食物奖励之间做出选择。我们发现行为证据的结果特异性转移效应在我们的科目，以及不同的血氧水平依赖性活动的腹外侧壳核区域时，分别选择，行动一致和不一致的巴甫洛夫预测的结果。我们的研究结果表明，选择一个与巴甫洛夫预测的结果不相容的行动可能需要抑制可行的，但非选择的行动-结果协会。这项研究的结果是相关的了解如何营销行为可以影响消费者的选择行为，以及如何环境线索可以影响药物成瘾的寻求行为。
In outcome-specific transfer, pavlovian cues that are predictive of specific outcomes bias action choice toward actions associated with those outcomes. This transfer occurs despite no explicit training of the instrumental actions in the presence of pavlovian cues. The neural substrates of this effect in humans are unknown. To address this, we scanned 23 human subjects with functional magnetic resonance imaging while they made choices between different liquid food rewards in the presence of pavlovian cues previously associated with one of these outcomes. We found behavioral evidence of outcome-specific transfer effects in our subjects, as well as differential blood oxygenation level-dependent activity in a region of ventrolateral putamen when subjects chose, respectively, actions consistent and inconsistent with the pavlovian-predicted outcome. Our results suggest that choosing an action incompatible with a pavlovian-predicted outcome might require the inhibition of feasible but nonselected action-outcome associations. The results of this study are relevant for understanding how marketing actions can affect consumer choice behavior as well as for how environmental cues can influence drug-seeking behavior in addiction.